作者:vanOnnaM翻译:张璐
发布者:郭越审校者:王振青
目的:
类风湿关节炎的目标治疗,需要有效检测关节炎症的工具。因此,影像学方式的检查越来越多地用于临床实践中。光谱传导(OST)测量为非侵入性,并且快速,因此可能存在优于现有的成像方式的方面。我们测试是否光谱传导能有效测量类风湿关节的疾病活动
方法:
纳入59位RA患者和0位关节痛患者,进行光谱传导、关节数、疾病活动性评分(DAS)28和超声(US)检测。此外,DAS.6的患者行MRI检查。我们以超声作为参考,在相同队列发现和验证,光谱传导对关节炎症检测的演算。
结果:
在关节水平,OST和超声对近段指间关节(ROC曲线下面积(AUC)为0.79,P<0.)掌指关节(AUC0.78,P<0.)评估水平相似。在腕关节表现不相同(AUC0.62,P=0.)。在病人个体水平,光谱传导与临床检查(DAS28r=0.42,p=0.00)和超声评分(r=0.64,p0.)相似,此外,对于亚临床低疾病活动的患者,OST和MRI滑膜炎评分呈正相关(RAMRIS(类风湿性关节炎的MRI评分)滑膜炎)。
结论:
在这项研究中,光谱传导对类风湿关节炎患者的关节炎症的检测适度。还需要进一步研究,在一个新的类风湿患者队列中确定其诊断性能。
附原文:
Abstract:OBJECTIVES:Inrheumatoidarthritis(RA),treat-to-targetstrategiesrequireinstrumentsforvaliddetectionofjointinflammation.Therefore,imagingmodalitiesareincreasinglyusedinclinicalpractice.Opticalspectraltransmission(OST)measurementsarenon-invasiveandfastandmaythereforehavebenefitsoverexistingimagingmodalities.WetestedwhetherOSTcouldmeasurediseaseactivityvalidlyinpatientswithRA.METHODS:In59patientswithRAand0patientswitharthralgia,OST,jointcounts,DiseaseActivityScore(DAS)28andultrasonography(US)wereperformed.Additionally,MRIwasperformedinpatientswithDAS.6.WedevelopedandvalidatedwithinthesamecohortanalgorithmfordetectionofjointinflammationbyOSTwithUSasreference.RESULTS:Atthejointlevel,OSTandUSperformedsimilarlyinproximalinterphalangeal-joints(areaunderthereceiver-operatingcurve(AUC)of0.79,p0.)andmetacarpophalangealjoints(AUC0.78,p0.).Performancewaslesssimilarinwrists(AUC0.62,p=0.).Onthepatientlevel,OSTcorrelatedmoderatelywithclinicalexamination(DAS28r=0.42,p=0.00),andUSscores(r=0.64,p0.).Furthermore,inpatientswithsubclinicalandlowdiseaseactivity,therewasacorrelationbetweenOSTandMRIsynovitisscore(RAMRIS(RheumatoidArthritisMRIScoring)synovitis),r=0.52,p=0..CONCLUSIONS:Inthispilotstudy,OSTperformedmoderatelyinthedetectionofjointinflammationinpatientswithRA.FurtherstudiesareneededtodeterminethediagnosticperformanceinanewcohortofpatientswithRA.
引自:
vanOnnaM,TenCateDF,TsoiKLetal,Assessmentofdiseaseactivityinpatientswithrheumatoidarthritisusingopticalspectraltransmissionmeasurements,anon-invasiveimagingtechnique.AnnRheumDis.Mar;75(3):5-8.doi:0.36